Broad-spectrum non-nucleoside inhibitors of human herpesviruses
نویسندگان
چکیده
منابع مشابه
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.
We synthesized new indolylarylsulfone (IAS) derivatives carrying a heterocyclic tail at the indole-2-carboxamide nitrogen as potential anti-HIV/AIDS agents. Several new IASs yielded EC50 values <1.0 nM against HIV-1 WT and mutant strains in MT-4 cells. The (R)-11 enantiomer proved to be exceptionally potent against the whole viral panel; in the reverse transcriptase (RT) screening assay, it was...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2015
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2015.06.005